The influence of thep53gene on the in vitro chemosensitivity of colorectal cancer cells
β Scribed by Minhua Zheng; Hao Wang; Haobo Zhang; Qishi Ou; Baihua Shen; Ningli Li; Baoming Yu
- Publisher
- Springer-Verlag
- Year
- 1999
- Tongue
- English
- Weight
- 77 KB
- Volume
- 125
- Category
- Article
- ISSN
- 1432-1335
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Abstract The cellular DNA content was measured from paraffin-embedded material in 134 colorectal cancers from patients in whom the outcome was known. Seventy-two (55 per cent) were found to contain cells with abnormal DNA (DNA aneuploid). The presence of such a population of cells was not related to
Distal colorectal cancers, especially those in the rectum, are more aggressive and more commonly recurrent than proximal cancers. We studied the possible relationship between p53-gene mutation type and location of the tumour, since mutations in the conserved areas of the p53 gene have been suggested