✦ LIBER ✦

The influence of tumour cell DNA abnormalities on survival in colorectal cancer

✍ Scribed by Mr N. C. Armitage; R. A. Robins; D. F. Evans; D. R. Turner; R. W. Baldwin; J. D. Hardcastle

Publisher: John Wiley and Sons
Year: 1985
Tongue: English
Weight: 301 KB
Volume: 72
Category: Article
ISSN: 0007-1323
DOI: 10.1002/bjs.1800721018

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract
The cellular DNA content was measured from paraffin-embedded material in 134 colorectal cancers from patients in whom the outcome was known. Seventy-two (55 per cent) were found to contain cells with abnormal DNA (DNA aneuploid). The presence of such a population of cells was not related to pathological stage or histological grade. However, only 14 (19 per cent) patients with DNA aneuploid tumours survived 5 years compared with 27 (43 per cent) of patients with diploid tumours (χ2 = 8·0, P = 0·005). Stepwise logistic analysis showed cellular DNA content to be an important prognostic factor in colorectal cancer, independent of pathological stage and histological grade.

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