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The influence of the thymus on multinucleate giant cell formation

โœ Scribed by J. M. Papadimitriou

Publisher
John Wiley and Sons
Year
1976
Tongue
English
Weight
233 KB
Volume
118
Category
Article
ISSN
0022-3417

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โœฆ Synopsis

Glass coverslips were implanted in nude athymic mice and normal controls and the development of multinucleated giant cells on the implant investigated. Although the percentage of the surface area of the coverslip covered by cellular exudate was reduced in older implants (12 days or more) in athymic mice, the proportion of nuclei within syncytia was the same as in normal controls. It is concluded that the multinucleated giant cells in this type of inflammatory lesion are not thymus derived nor is the efficiency of fusion between their precursor mononuclear phagocytes thymus dependent. The number of exuded mononuclear phagocytes on the other hand may be influenced directly or indirectly by the thymus.

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## Abstract The relative magnitude of the negative charge per unit area on the surface of resident and exudate macrophages as well as multinucleate giant cells was assessed by cytophotometric and ultrastructural techniques. The results indicate that the surface of resident macrophages possesses a h