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The influence of Sodium on the electrical and mechanical activity of the ureter

โœ Scribed by Hendrickx, H. ;Vereecken, R.L. ;Casteels, R.

Publisher
Springer
Year
1975
Tongue
English
Weight
346 KB
Volume
3
Category
Article
ISSN
0300-5623

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โœฆ Synopsis

In Sodium-deficient solutions both the electrical and mechanical activity of the ureter are reduced. The plateau component of the action potential in the smooth muscle cell of the guinea pig ureter is more affected than the oscillations. Tetrodotoxin, which blocks the action potential in nerves, does not influence activity or conduction in the ureter. This is an important argument for the myogenic conduction of activity in this tissue.

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Increase of the external K+ concentration depolarises the ureteral muscle membrane and induces, after a transient period of increased spontaneous activity, a tonic contraction. Tetraethylammonium, in concentrations normally required for ganglion blocking activity, does not influence the ureteral act