The influence of protein solubilisation, conformation and size on the burst release from poly(lactide-co-glycolide) microspheres
β Scribed by Gayle Duncan; Thomas J. Jess; Farahidah Mohamed; Nicholas C. Price; Sharon M. Kelly; Christopher F. van der Walle
- Book ID
- 113691054
- Publisher
- Elsevier Science
- Year
- 2005
- Tongue
- English
- Weight
- 602 KB
- Volume
- 110
- Category
- Article
- ISSN
- 0168-3659
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In this article, microspheres able to induce the controlled release of oligonucleotide/polyethylenimine complexes are proposed. A model oligonucleotide (the oligothymidilate pdT16) was encapsulated within poly(lactide-co-glycolide) microspheres alone or associated with polyethylenimine (PEI) at diff
Despite the recognised role of the poly(lactide-co-glycolide) (PLGA) in the encapsulation and release of proteins from PLGA microspheres, the importance that the characteristics of the protein have in these processes has not yet been sufficiently investigated. The aim of this work was to study the s