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The influence of protein solubilisation, conformation and size on the burst release from poly(lactide-co-glycolide) microspheres

✍ Scribed by Gayle Duncan; Thomas J. Jess; Farahidah Mohamed; Nicholas C. Price; Sharon M. Kelly; Christopher F. van der Walle


Book ID
113691054
Publisher
Elsevier Science
Year
2005
Tongue
English
Weight
602 KB
Volume
110
Category
Article
ISSN
0168-3659

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Despite the recognised role of the poly(lactide-co-glycolide) (PLGA) in the encapsulation and release of proteins from PLGA microspheres, the importance that the characteristics of the protein have in these processes has not yet been sufficiently investigated. The aim of this work was to study the s