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Protein encapsulation and release from poly(lactide-co-glycolide) microspheres: effect of the protein and polymer properties and of the co-encapsulation of surfactants

✍ Scribed by Dolores Blanco; Marı́a J Alonso

Book ID
115543613
Publisher
Elsevier Science
Year
1998
Tongue
French
Weight
503 KB
Volume
45
Category
Article
ISSN
0939-6411

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Protein encapsulation and release from p
Protein encapsulation and release from poly(lactide-co-glycolide) microspheres: effect of the protein and polymer properties and of the co-encapsulation of surfactants
✍ Dolores Blanco; Marı́a J Alonso 📂 Article 📅 1998 🏛 Elsevier Science 🌐 French ⚖ 503 KB

Despite the recognised role of the poly(lactide-co-glycolide) (PLGA) in the encapsulation and release of proteins from PLGA microspheres, the importance that the characteristics of the protein have in these processes has not yet been sufficiently investigated. The aim of this work was to study the s

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In this study, we created ciprofloxacin.HCl (CIP)-encapsulated poly(DL-lactide-co-glycolide) (PLGA) microspheres by the solvent evaporation method. Their antibacterial activity was evaluated with pathogenic microorganisms in vitro and in vivo. Since the half-life of CIP in the blood stream is short,