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The influence of nuclear background on the biochemical expression of 3460 Leber's hereditary optic neuropathy

✍ Scribed by H. R. Cock; S. J. Tabrizi; J. M. Cooper; Dr. A. H. V. Schapira

Book ID: 102708382
Publisher: John Wiley and Sons
Year: 1998
Tongue: English
Weight: 866 KB
Volume: 44
Category: Article
ISSN: 0364-5134
DOI: 10.1002/ana.410440208

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Leber hereditary optic neuropathy (LHON) is a major cause of inherited blindness in young males. Approximately 1 in 7 individuals with LHON harbor a mixture of mutated and wild-type (normal) mtDNA (heteroplasmy), and the risks of developing blindness in heteroplasmic LHON individuals are not well ch