Clinical Expression of Leber Hereditary Optic Neuropathy Is Affected by the Mitochondrial DNA–Haplogroup Background
✍ Scribed by Gavin Hudson; Valerio Carelli; Liesbeth Spruijt; Mike Gerards; Catherine Mowbray; Alessandro Achilli; Angela Pyle; Joanna Elson; Neil Howell; Chiara La Morgia; Maria Lucia Valentino; Kirsi Huoponen; Marja-Liisa Savontaus; Eeva Nikoskelainen; Alfredo A. Sadun; Solange R. Salomao; Rubens Belfort Jr.; Philip Griffiths; Patrick Yu Wai Man; Rene F.M. de Coo; Rita Horvath; Massimo Zeviani; Hubert J.T. Smeets; Antonio Torroni; Patrick F. Chinnery
- Book ID
- 117855224
- Publisher
- American Society of Human Genetics
- Year
- 2007
- Tongue
- English
- Weight
- 103 KB
- Volume
- 81
- Category
- Article
- ISSN
- 0002-9297
- DOI
- 10.1086/519394
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
Leber hereditary optic neuropathy (LHON) is a major cause of inherited blindness in young males. Approximately 1 in 7 individuals with LHON harbor a mixture of mutated and wild-type (normal) mtDNA (heteroplasmy), and the risks of developing blindness in heteroplasmic LHON individuals are not well ch