Haplogroup Effects and Recombination of Mitochondrial DNA: Novel Clues from the Analysis of Leber Hereditary Optic Neuropathy Pedigrees
β Scribed by Valerio Carelli; Alessandro Achilli; Maria Lucia Valentino; Chiara Rengo; Ornella Semino; Maria Pala; Anna Olivieri; Marina Mattiazzi; Francesco Pallotti; Franco Carrara; Massimo Zeviani; Vincenzo Leuzzi; Carla Carducci; Giorgio Valle; Barbara Simionati; Luana Mendieta; Solange Salomao; Rubens Belfort Jr.; Alfredo A. Sadun; Antonio Torroni
- Book ID
- 117854778
- Publisher
- American Society of Human Genetics
- Year
- 2006
- Tongue
- English
- Weight
- 693 KB
- Volume
- 78
- Category
- Article
- ISSN
- 0002-9297
- DOI
- 10.1086/501236
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π SIMILAR VOLUMES
Leber hereditary optic neuropathy (LHON) is a major cause of inherited blindness in young males. Approximately 1 in 7 individuals with LHON harbor a mixture of mutated and wild-type (normal) mtDNA (heteroplasmy), and the risks of developing blindness in heteroplasmic LHON individuals are not well ch