The influence of ICRF-159 and levamisole on the incidence of metastases following local irradiation of a solid tumor

✍ Scribed by Donald Baker; William Constable; David Elkon; Lucille Rinehart

• Publisher: John Wiley and Sons
• Year: 1981
• Tongue: English
• Weight: 461 KB
• Volume: 48
• Category: Article
• ISSN: 0008-543X
• DOI: 10.1002/1097-0142(19811115)48:10<2179::aid-cncr2820481011>3.0.co;2-u

✦ Synopsis

Courses of irradiation consisting of 6000 rad in ten equal fractions over 12 days delivered to KHT sarcomas in mice controlled 55% of the local tumors but 83% of the mice died from metastases. Three strategies to reduce the risk of metastatic spread were tested. The fractionation scheme was changed to deliver the same total dose using a large initial fraction followed by seven equal portions with the same overall time. ICRF-159 was used with the intention of partially synchronizing the tumor growth fraction in a radiosensitive state of the growth cycle and of promoting normalization of the tumor vasculature. Levamisole was used to stimulate the immune system. The combination of ICRF-159 with the eight-fraction radiation course proved to he effective for both increasing local control and decreasing the incidence of metastases. The addition of levamisole did not improve the results obtained with a combination of ICRF-159 and irradiation.