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The influence of hepatic microsomal amidopyrine demethylase activity on halothane hepatotoxicity in the horse

โœ Scribed by G. Gopinath; E. J. H. Ford

Publisher
John Wiley and Sons
Year
1976
Tongue
English
Weight
536 KB
Volume
119
Category
Article
ISSN
0022-3417

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โœฆ Synopsis

The hepatotoxic effect of oral halothane in the horse is increased by pretreatment with phenobarbitone or DDT but not by chlorpromazine. Phenobarbitone and DDT increase the activity of hepatic amidopyrine N-demethylase but chlorpromazine does not. Carbon disulphide protects the liver of the horse against halothane.

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