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The influence of amines on the rates of the Zn(II) catalyzed decarboxylation of oxaloacetate

โœ Scribed by Ralph K. Steinhaus; N.V. Raghavan; Daniel L. Leussing


Book ID
115974731
Publisher
Elsevier Science
Year
1977
Weight
473 KB
Volume
39
Category
Article
ISSN
0022-1902

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A designed single amino acid substitution can alter the catalytic activity and mechanism of 4-oxalocrotonate tautomerase (4-OT). While the wild-type enzyme catalyzes only the tautomerization of oxalocrotonate, the Pro1Ala mutant (P1A) catalyzes two reactions--the original tautomerization reaction an