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The influence of age on the distribution of morphine and morphine-3-glucuronide across the blood–brain barrier in sheep

✍ Scribed by J Bengtsson; P Ederoth; D Ley; S Hansson; I Amer-Wåhlin; L Hellström-Westas; K Marsál; C-H Nordström; M Hammarlund-Udenaes

Book ID
111219170
Publisher
Nature Publishing Group
Year
2009
Tongue
English
Weight
477 KB
Volume
157
Category
Article
ISSN
0007-1188

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Pharmacokinetics and pharmacodynamics of
Pharmacokinetics and pharmacodynamics of morphine-3-glucuronide in rats and its influence on the antinociceptive effect of morphine
✍ Marianne Ekblom; Marie Gårdmark; Margareta Hammarlund-Udenaes 📂 Article 📅 1993 🏛 John Wiley and Sons 🌐 English ⚖ 555 KB

In this study the pharmacokinetics and pharmacodynamics of morphine-3-glucuronide (M3G) were investigated in rats after i.v. administration as a bolus dose (86.7 pmol kg-I) and as a constant rate infusion (2.9 pmol h-') over 5 days. After the bolus dose, the clearance (Cl) was 12.1 ~0.6mlmin-\*\*kg,