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The influence of morphine-3-glucuronide on the anti-nociceptive and respiratory effects of morphine in rats

✍ Scribed by M. Gärdmark; F. Jonsson; M. Hammaerlund-Udenaes

Book ID
117628758
Publisher
Elsevier Science
Year
1996
Tongue
English
Weight
162 KB
Volume
4
Category
Article
ISSN
0928-0987

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Pharmacokinetics and pharmacodynamics of
Pharmacokinetics and pharmacodynamics of morphine-3-glucuronide in rats and its influence on the antinociceptive effect of morphine
✍ Marianne Ekblom; Marie Gårdmark; Margareta Hammarlund-Udenaes 📂 Article 📅 1993 🏛 John Wiley and Sons 🌐 English ⚖ 555 KB

In this study the pharmacokinetics and pharmacodynamics of morphine-3-glucuronide (M3G) were investigated in rats after i.v. administration as a bolus dose (86.7 pmol kg-I) and as a constant rate infusion (2.9 pmol h-') over 5 days. After the bolus dose, the clearance (Cl) was 12.1 ~0.6mlmin-\*\*kg,