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The influence of acids on 4-benzyl-1,2-dihydroisoquinoline derivatives

✍ Scribed by D.W. Brown; S.F. Dyke; M. Palfreyman; M. Sainsbury


Book ID
104212392
Publisher
Elsevier Science
Year
1968
Tongue
French
Weight
180 KB
Volume
9
Category
Article
ISSN
0040-4039

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Differentiation of isomeric 1,2-dihydroi
✍ Roger D. Waigh 📂 Article 📅 1980 🏛 John Wiley and Sons 🌐 English ⚖ 137 KB

## Abstract Reaction of a 3,3‐dimethyl‐1,2‐dihydroisoquinolin‐4(3__H__)‐one with a benzyl Grignard reagent gives a 4‐benzyltetrahydroisoquinoline in which the signal of a 6‐methoxy group suffers a large upfield shift in the ^1^H NMR spectrum, whereas a 7‐methoxy group is relatively unaffected. This