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The induction of glycogenolysis in the perfused liver by platelet activating factor is mediated by prostaglandin D2 from Kupffer cells

✍ Scribed by Johan Kuiper; Yolanda B. De Rijke; Freek J. Zijlstra; Marieke P. Van Waas; Theo J.C. Van Berkel


Book ID
117058460
Publisher
Elsevier Science
Year
1988
Tongue
English
Weight
398 KB
Volume
157
Category
Article
ISSN
0006-291X

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Excessive nitric oxide (NO) generated by hepatic cells in response to lipopolysaccharide (LPS) and inflammatory substances (e.g., platelet-activating factor [PAF]) is a key contributor to the pathophysiological outcomes observed in the liver during sepsis. In rats subjected to liver-focused endotoxe