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Induction of cyclooxygenase-2 and prostaglandin E2 biosynthesis by epithelial cell derived factors is mediated mainly by p42/p44 mitogen-activated protein (MAP) kinase in stromal cells in endometrium.

✍ Scribed by M Tamura; S Yang; B Gurates; Z Fang; S Sebastian; S.E Bulun

Book ID: 119417625
Publisher: Elsevier Science
Year: 2001
Tongue: English
Weight: 36 KB
Volume: 76
Category: Article
ISSN: 1556-5653
DOI: 10.1016/s0015-0282(01)02317-2

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Several agents that act through G-protein-coupled receptors and also stimulate phosphoinositide-specific phospholipase C (PI-PLC), including angiotensin II, vasopressin, norepinephrine, and prostaglandin (PG) F 2a , activated the ERK1 (p44 mapk ) and ERK2 (p42 mapk ) members of the mitogen-activated