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The induction of functional vitamin B-12 deficiency in rats by exposure to nitrous oxide

โœ Scribed by McKenna, B.; Weir, D.G.; Scott, J.M.


Book ID
123559842
Publisher
Elsevier Science
Year
1980
Tongue
English
Weight
521 KB
Volume
628
Category
Article
ISSN
0304-4165

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Exposure to nitrous oxide interferes selectively with the coenzyme function of vitamin B12 and causes inactivation of methionine synthetase, with subsequent impairment of folate metabolism and reduction of cellular proliferation. In a rat leukemia model (BNML) we investigated the combined administra