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Urinary folate loss following inactivation of vitamin B12 by nitrous oxide in rats

โœ Scribed by M. Lumb; Janet Perry; Rosemary Deacon; I. Chanarin


Book ID
114709714
Publisher
John Wiley and Sons
Year
1982
Tongue
English
Weight
419 KB
Volume
51
Category
Article
ISSN
0007-1048

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Exposure to nitrous oxide interferes selectively with the coenzyme function of vitamin B12 and causes inactivation of methionine synthetase, with subsequent impairment of folate metabolism and reduction of cellular proliferation. In a rat leukemia model (BNML) we investigated the combined administra