β Scribed by Brodberg, R. K. ;Lyman, R. F. ;Woodruff, R. C.
No coin nor oath required. For personal study only.
We have determined the in vivo effects of cis-platinum@)diamminodichloride (cis-PDD) treatment on the induction of chromosome aberrations in Drosophila melanogaster germ cells. cis-PDD treatment induces significant increases in clue mosome breakage in all stages of spermatogenesis in a battery of test systems using ring or rod-X males and repair-proficient or deficient females. Since no increase in nondisjunction was induced by cis-PDD in either male or female germ cells, any aneuploidy inducing effects of this compound should result from its clastogenic action. We also find that mei-9 excision repair function is involved in the repair of cis-PDD-induced DNA lesions in a manner that provides additional evidence that partial and ring chromosome losses are not completely homologous.
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