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The increased CAR-dependent metabolism of thyroid hormones in mice with high cancer susceptibility

✍ Scribed by Maria Pakharukova; Mariya Smetanina; Vasily Kaledin; Timofey Obut; Tatiana Merkulova

Book ID
116719849
Publisher
Elsevier Science
Year
2010
Tongue
English
Weight
391 KB
Volume
87
Category
Article
ISSN
0024-3205

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## Background: Germ-line and sporadic mutations in the tumor suppressor gene pten (also known as mmac or tep1), which encodes a dual-specificity phosphatase, cause a variety of cancers such as cowden disease, glioblastoma, endometrial carcinoma and prostatic cancer. pten is widely expressed, and co