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The in vivo mutagenicity and mutational spectrum at the lacI transgene recovered from the spleens of B6C3F1 lacI transgenic mice following a 4-week inhalation exposure to 1,3-butadiene

✍ Scribed by Leslie Recio; Linda J Pluta; Kathy G Meyer

Book ID: 114071513
Publisher: Elsevier Science
Year: 1998
Tongue: English
Weight: 102 KB
Volume: 401
Category: Article
ISSN: 0027-5107
DOI: 10.1016/s0027-5107(97)00319-9

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W e have examined the spectra of mutations in a collection of 7 4 lac1 mutants isolated from the bone marrow of B6C3F1 lac1 transgenic mice exposed to 1,250 ppm 1,3-butadiene (BD). Of the 49 inde pendent mutations analyzed in the present study, 30 of 49 (61 %) were point mutations at G:C base pairs,