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The in vivo characteristics of genetically engineered divalent and tetravalent single-chain antibody constructs

✍ Scribed by Uwe A. Wittel; Maneesh Jain; Apollina Goel; Subhash C. Chauhan; David Colcher; Surinder K. Batra


Book ID
116798836
Publisher
Elsevier Science
Year
2005
Tongue
English
Weight
478 KB
Volume
32
Category
Article
ISSN
0969-8051

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## Abstract Here we characterize the antitumor activity of a recombinant bispecific single‐chain antibody isolated from the serum of cloned transgenic cows. The antibody, termed r28M, is directed to a melanoma‐associated proteoglycan, also expressed on glioblastoma cells, and to human CD28. Bound t