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The in vivo antifungal activity of broad-spectrum azoles

✍ Scribed by Jan van Cutsem; Frans van Gerven


Publisher
John Wiley and Sons
Year
1986
Tongue
English
Weight
433 KB
Volume
8
Category
Article
ISSN
0272-4391

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Synthesis and in vitro and in vivo Antif
✍ Lieven Meerpoel; Jan Heeres; Leo J.β€…J. Backx; Louis J.β€…E. Vanβ€…der Veken; Rob Hen πŸ“‚ Article πŸ“… 2010 πŸ› John Wiley and Sons 🌐 English βš– 344 KB πŸ‘ 1 views

## Abstract __Herein we describe the scalable diastereoselective and enantioselective syntheses of eight enantiomers of hydroxy metabolites of saperconazole. The inβ€…vitro antifungal activity of the eight stereoisomers (compounds **1**–**8**) was compared against a broad panel of__ Candida__spp. (__