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The in vitro/in vivo comparative metabolism of 4-aminobiphenyl using isolated hepatocytes

โœ Scribed by S. D. Jatoe; J. W. Gorrod

Publisher
Springer-Verlag
Year
1987
Tongue
English
Weight
340 KB
Volume
60
Category
Article
ISSN
0340-5761

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## Background: Flobufen (f) is an original nonsteroidal anti-inflammatory drug with one center of chirality. 4-dihydroflobufen (dhf), compound with two chiral centers, is the main metabolite of f in microsomes and cytosol in all standard laboratory animals. this work describes the biotransformation