Periportal (pp) and perivenous (pv) hepatocyte populations were separated using a two-directional closed perfusion technique with selective addition of collagenase either to direct or retrograde perfusions (VÀÀnÀnen, H. et al., Liver 1983; 3:131). The activity of GPT in hepatocytes from the pp-area
Comparative metabolism of bis(2-methoxyethyl)ether in isolated rat hepatocytes and in the intact rat: Effects of ethanol on in vitro metabolism
β Scribed by Donald E. Richards; Karen B. Begley; D. Gayle DeBord; Kenneth L. Cheever; Walter W. Weigel; Mark A. Tirmenstein; Russell E. Savage
- Publisher
- Springer-Verlag
- Year
- 1993
- Tongue
- English
- Weight
- 793 KB
- Volume
- 67
- Category
- Article
- ISSN
- 0340-5761
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Cocaine remains a widely abused illicit substance in our society. Cocaine hepatotoxicity has been linked to cocaine metabolism. Cocaine can undergo hydrolytic inactivation via plasma and hepatic esterases or it can be N-oxidized by cytochrome P-450 and FAD-containing monooxygenases. Ethanol is frequ