The improved biological properties in mice of 99mTc–TBI for myocardial perfusion imaging

✍ Scribed by X. Zh. Zhang; X. B. Wang; Z. G. Tang

• Publisher: John Wiley and Sons
• Year: 2001
• Tongue: French
• Weight: 78 KB
• Volume: 44
• Category: Article
• ISSN: 0022-2135
• DOI: 10.1002/jlcr.493

✦ Synopsis

Abstract

The aim of this study was to improve the biological properties of ^99m^Tc–TBI complex for myocardial perfusion imaging. The effect of Tween‐80 on the biodistribution in mice of ^99m^Tc–TBI was reported. The experimental results show that liver and blood uptakes of Tween‐80 added (TA) complex are significantly lower than those of corresponding non‐Tween‐80 added (NTA) complex. Also, the clearance rate from blood of TA complex is faster than that of NTA complex. At 60 min post‐injection time, the ratios of heart‐to‐liver, heart‐to‐lung and heart‐to‐blood were 1.29, 137.75 and 4.73, respectively, for the TA complex; however, the corresponding ratios were 0.57, 13.07 and 2.65, respectively, for NTA complex. The biodistribution in mice of the Tween‐80 added ^99m^Tc–TBI (^99m^Tc–TBI(T)) is comparable with the widely used myocardial perfusion imaging agent ^99m^Tc–MIBI in some aspects; especially, the heart‐to‐liver ratios of ^99m^Tc–TBI(T) at various post‐injection times are better than those of ^99m^Tc–MIBI. The biological properties of ^99m^Tc–TBI complex for myocardial imaging were improved significantly by using Tween‐80 as an auxiliary agent. It is worthy of further studies. Copyright © 2001 John Wiley & Sons, Ltd.