Single- or dual-bolus approach for the assessment of myocardial perfusion reserve in quantitative MR perfusion imaging
✍ Scribed by Wolfgang Utz; Andreas Greiser; Thoralf Niendorf; Rainer Dietz; Jeanette Schulz-Menger
- Publisher
- John Wiley and Sons
- Year
- 2008
- Tongue
- English
- Weight
- 442 KB
- Volume
- 59
- Category
- Article
- ISSN
- 0740-3194
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✦ Synopsis
Abstract
A dual‐bolus protocol can overcome limitations due to T1‐induced MR signal attenuation and hence enables more accurate quantification of myocardial blood flow (MBF) by contrast enhanced MR perfusion imaging. The study explores potential benefits of the dual‐bolus technique for the assessment of myocardial perfusion reserve (MPR) over a standard single‐bolus protocol. Nineteen patients without obstructive coronary artery disease as assessed by cardiac catheterization underwent a stress‐rest MR perfusion study using a dual‐bolus protocol. Gd‐DTPA dosages of 0.005 and 0.05 mmol/kg of bodyweight were delivered as pre‐ and main‐bolus. For comparison arterial input curves where extracted from left ventricular cavity passage including both, pre‐bolus and main‐bolus data. Global and segmental MPR were determined from semiquantitative and from full quantitative measures of MBF. As a result good agreement between dual‐ and single‐bolus technique was found with relative differences of maximally 10% in global MPR estimates. For the dual bolus approach a significant relative decrease of 30% (P < 0.001) was found for the coefficient of segmental MPR variation, which may allow a more reliable detection of hypoperfused segments in clinical studies. Magn Reson Med 59:1373–1377, 2008. © 2008 Wiley‐Liss, Inc.