The important role of albumin in determining the relative human blood stabilities of the camptothecin anticancer drugs
β Scribed by Thomas G. Burke; Cyrus B. Munshi; Zihou Mi; Ying Jiang
- Publisher
- John Wiley and Sons
- Year
- 1995
- Tongue
- English
- Weight
- 265 KB
- Volume
- 84
- Category
- Article
- ISSN
- 0022-3549
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π SIMILAR VOLUMES
Although base-catalyzed addition of PhSH to PhCECCF3 under thermodynamic control gives E\_Ph(PhS)C=CH(CF3), .?+Ph(PhO)C=CH(CF3) is the thermodynamically favored product from similar reaction of PhOH with PhCXCF3. The preference for the +-configuration of CF3 and PhO on a double bond is rationalized
Methods were developed for the determination of octanoic acid and N-acetyl-DL-tryptophan, which are used as stabilizers in the human blood-derived therapeutic products normal serum albumin and plasma protein fraction. The method for octanoic acid uses GC; quantitation is achieved using heptanoic aci