The Importance of Wnt Signaling in Cardiovascular Development
โ Scribed by Ying Tian; Ethan David Cohen; Edward E. Morrisey
- Publisher
- Springer
- Year
- 2009
- Tongue
- English
- Weight
- 192 KB
- Volume
- 31
- Category
- Article
- ISSN
- 0172-0643
No coin nor oath required. For personal study only.
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## Abstract In the past twenty years, secreted signaling molecules of the Wnt family have been found to play a central role in controlling embryonic development from hydra to human. In the developing vertebrate limb, Wnt signaling is required for limb bud initiation, early limb patterning (which is
Wnt signaling regulates many aspects of vertebrate development and adult stem cells. Deregulation of Wnt signaling causes development defect and cancer. The signaling is categorized in two pathways: canonical and noncanonical. Both pathways are initiated by Wnt ligands and Frizzled receptors. Canoni