The importance of voltage-dependent sodium channels in cerebral ischaemia
β Scribed by A. J. Carter
- Book ID
- 105164801
- Publisher
- Springer
- Year
- 1998
- Tongue
- English
- Weight
- 876 KB
- Volume
- 14
- Category
- Article
- ISSN
- 0939-4451
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## Abstract Global ischemia was induced in gerbil by bilateral occlusion of the common carotid arteries for 5 min. Sodium ionophore monensin or sodium channel blocker tetrodotoxin (TTX) was administered at doses of 10 ΞΌg/kg, i.p., 30 min before ischemia induction; the dose was repeated after 22 hr.
The voltage-dependent K + channels of the mammalian sarcolemma were studied with the patchclamp technique in intact, enzymatically dissociated fibres from the toe muscle of the mouse. With a physiological solution (containing 2.5 mM K Β§ in the pipette, depolarizing pulses imposed on a cell-attached