𝔖 Bobbio Scriptorium
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The importance of the phenyl-tropolone ‘aS’ configuration in colchicine's binding to tubulin

✍ Scribed by Herman J.C. Yeh; Maria Chrzanowska; Arnold Brossi

Book ID
115920919
Publisher
Elsevier Science
Year
1988
Tongue
English
Weight
278 KB
Volume
229
Category
Article
ISSN
0014-5793

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✍ Mina E. Holm Nygaard; John M. Dornish; Reidar Oftebro; Kjell Undheim 📂 Article 📅 1986 🏛 Springer US 🌐 English ⚖ 948 KB

The effect of 2-(2-thenyl)sulfonyl-5-bromopyrimidine (NY 4137) on cells of the human line NHIK 3025 was investigated. It was shown that NY 4137 induces cell cycle specific inhibition in metaphase. A dose-dependent prolongation of metaphase was found and the fraction of cells able to escape metaphase