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The importance of human glandular kallikrein and its correlation with different prostate specific antigen serum forms in the detection of prostate carcinoma

✍ Scribed by Franz Recker; Maciej K. Kwiatkowski; Timo Piironen; Kim Pettersson; Gerd Lümmen; Martin Wernli; Johannes Wiefelspütz; Samuel F. Graber; Mark Goepel; Andreas Huber; Reto Tscholl


Publisher
John Wiley and Sons
Year
1998
Tongue
English
Weight
116 KB
Volume
83
Category
Article
ISSN
0008-543X

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✦ Synopsis


BACKGROUND.

Human glandular kallikrein (hK2), the prostate specific antigen (PSA) close homologue, possesses approximately 80% structure identity with PSA.

The identification of PSA was an important step in the detection of prostate carcinoma (PCa). Thus, hK2 measurement in the serum has the potential to become another important diagnostic test for PCa. In the current study, the authors measured the serum concentrations of the hK2 with "in-house" immunofluorometric assays in different patient groups. The correlation between serum hK2 and different PSA forms was investigated.


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