The influence of prostate volume on the ratio of free to total prostate specific antigen in serum of patients with prostate carcinoma and benign prostate hyperplasia

✍ Scribed by Carsten Stephan; Michael Lein; Klaus Jung; Dietmar Schnorr; Stefan A. Loening

• Publisher: John Wiley and Sons
• Year: 1997
• Tongue: English
• Weight: 102 KB
• Volume: 79
• Category: Article
• ISSN: 0008-543X
• DOI: 10.1002/(sici)1097-0142(19970101)79:1<104::aid-cncr15>3.0.co;2-8

✦ Synopsis

T1, 2, 3pN0, M0), 44 patients with BPH, and 54 healthy Charite ´, Humboldt University Berlin, Berlin, Gercontrols. Prostate volume was determined by transrectal ultrasound. many.

RESULTS.

The median values of t-PSA and f-PSA% were 7.8 mg/L and 10.5% in PCa patients, 4.3 mg/L and 20.8% in patients with BPH, and 1.4 mg/L and 23.6% in the control group. Patients with PCa had a significantly lower proportion of f-PSA than BPH patients and healthy men. There was no correlation of f-PSA% to TNM stage or tumor grade. In PCa patients a significant positive correlation (correlation coefficient [r] Å 0.51, P õ 0.001) was found between f-PSA% and prostate volume, whereas there was no significant correlation in BPH patients (r Å 00.27, P ú 0.05). There was a significant difference in f-PSA% between PCa and BPH patients with prostate volumes smaller than 40 cm 3 (9.0% vs. 21.6%, P õ 0.01) but not between patients in these 2 groups with prostate volumes exceeding 40 cm 3 (15.1% vs. 18.2%, P Å 0.11).

CONCLUSIONS.

Determining the ratio of f-PSA to t-PSA to discriminate between PCa and BPH patients yields significant results only in men with a prostate volume of less than 40 cm 3 . Cancer 1997; 79:104-9.