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The importance of genomic copy number changes in the prognosis of glioblastoma multiforme

✍ Scribed by Ali Arslantas; Sevilhan Artan; Ülkü Öner; Hamza Müslümanoğlu; Ramazan Durmaz; Erhan Cosan; MetinAnt Atasoy; Nurettin Başaran; Eşref Tel

Publisher
Springer-Verlag
Year
2004
Tongue
English
Weight
157 KB
Volume
27
Category
Article
ISSN
0344-5607

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## Abstract Loss of both __RB1__ alleles is rate limiting for development of retinoblastoma (RB), but genomic copy number gain or loss may impact oncogene(s) and tumor suppressor genes, facilitating tumor progression. We used quantitative multiplex polymerase chain reaction to profile “hot spot” ge