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Hypermethylation of the proapoptotic geneTMS1/ASC: prognostic importance in glioblastoma multiforme

✍ Scribed by Ramon Martinez; Gabriele Schackert; Manel Esteller

Publisher
Springer US
Year
2006
Tongue
English
Weight
279 KB
Volume
82
Category
Article
ISSN
0167-594X

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✍ Maurizio Martini; Roberto Pallini; Giuseppe Luongo; Tonia Cenci; Corrado Lucanto 📂 Article 📅 2008 🏛 John Wiley and Sons 🌐 French ⚖ 416 KB

## Abstract Alterations in the signal transduction pathways are key mechanisms in the pathogenesis of __de novo__ glioblastoma multiforme (GBM), which are also involved in the resistance to chemo‐ and radiotherapy. Here, we analyzed the methylation status and mRNA expression of suppressor of cytoki