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The importance of cysteine 126 in the human liver UDP-glucuronosyltransferase UGT1A6

✍ Scribed by Claire Senay; Gabriele Jedlitschky; Nadège Terrier; Brian Burchell; Jacques Magdalou; Sylvie Fournel-Gigleux


Book ID
114149209
Publisher
Elsevier Science
Year
2002
Tongue
English
Weight
169 KB
Volume
1597
Category
Article
ISSN
0167-4838

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Chenodeoxycholic acid (CDCA) is a liver-formed detergent and plays an important role in the control of cholesterol homeostasis. During cholestasis, toxic bile acids (BA) accumulate in hepatocytes causing damage and consequent impairment of their function. Glucuronidation, a conjugation reaction cata