✦ LIBER ✦

The importance of CD25+CD4+ regulatory T cells in mouse hepatic allograft tolerance

✍ Scribed by Xiaofeng Jiang; Miwa Morita; Atsushi Sugioka; Michishige Harada; Satoshi Kojo; Hiroshi Wakao; Hiroshi Watarai; Nobuhiro Ohkohchi; Masaru Taniguchi; Ken-ichiro Seino

Publisher: John Wiley and Sons
Year: 2006
Tongue: English
Weight: 309 KB
Volume: 12
Category: Article
ISSN: 1527-6465
DOI: 10.1002/lt.20787

No coin nor oath required. For personal study only.

✦ Synopsis

In mouse liver transplantation, tolerance is readily inducible. Recent studies have revealed that CD25+ CD4+ regulatory T cells play an important role in regulating various immune responses, including transplant tolerance. However, the contribution of these cells to tolerance in mouse liver transplantation has not been elucidated. We showed here that depletion of CD25+ CD4+ T cells increased proliferative response of CD4+ T cells and cytotoxic T lymphocyte induction of CD8+ T cells. Depletion of these cells in the recipient but not in the donor before liver transplantation caused rejection. Furthermore, the number of CD25+ CD4+ population and forkhead/winged helix transcription factor expression in liver mononuclear lymphocytes derived from tolerant mice were higher than those from grafts undergoing rejection. In conclusion, these results indicate that CD25+ CD4+ regulatory T cells in the recipient but not in the donor of liver transplantation are important for the tolerance induction.

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