Inhibition of human T cell proliferation
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ClaireβN. Manzotti; Helen Tipping; LauraβC.βA. Perry; KarenβI. Mead; PatrickβJ.
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Article
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2002
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John Wiley and Sons
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English
β 263 KB
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CD28 and CTLA-4 are opposing regulators of T cell activation, triggered by the two ligands CD80 and CD86. How these ligands promote either T cell activation via CD28 or inhibition via CTLA-4 is not understood. Using CD80 and CD86 molecules expressed on transfected cells, we have identified a major d