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The Importance of Adenosine Deaminase for Lymphocyte Development and Function

✍ Scribed by Melissa B. Aldrich; Michael R. Blackburn; Rodney E. Kellems


Book ID
115585859
Publisher
Elsevier Science
Year
2000
Tongue
English
Weight
182 KB
Volume
272
Category
Article
ISSN
0006-291X

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## Abstract For murine adenosine deaminase, we have determined that a single zinc or cobalt cofactor bound in a high affinity site is required for catalytic function while metal ions bound at an additional site(s) inhibit the enzyme. A catalytically inactive apoenzyme of murine adenosine deaminase