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The impact of the regulatory design on the response of epidermal growth factor receptor-mediated signal transduction towards oncogenic mutations

✍ Scribed by Jana Wolf; Serge Dronov; Frank Tobin; Igor Goryanin

Book ID: 111312112
Publisher: John Wiley and Sons
Year: 2007
Tongue: English
Weight: 1008 KB
Volume: 274
Category: Article
ISSN: 1432-1327
DOI: 10.1111/j.1742-4658.2007.06066.x

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## Abstract ## BACKGROUND. Epidermal growth factor receptor tyrosine kinase inhibitors (EGFR‐TKIs) have demonstrated clinical benefit in patients with nonsmall cell lung cancer (NSCLC), particularly those with tumors that have EGFR‐TK domain mutations. Moreover, the EGFR and cyclooxygenase (COX)‐2