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Effect of Epidermal Growth Factor Receptor Mutations on the Response to Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors: Target-Based Populations for Target-Based Drugs

✍ Scribed by Emiliano Calvo; Manuel K. Rowinsky


Book ID
115076575
Publisher
CIG Media Group, LP.
Year
2004
Tongue
English
Weight
204 KB
Volume
6
Category
Article
ISSN
1525-7304

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## Abstract ## BACKGROUND: Somatic mutations in the epidermal growth factor receptor (EGFR) kinase domain are associated with sensitivity to EGFR‐tyrosine kinase inhibitors (EGFR‐TKI) in patients with nonsmall cell lung cancer (NSCLC). ## METHODS: The authors tested the possibility that nucleoti