𝔖 Bobbio Scriptorium
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The impact of somatic mutation on antibody specificity

✍ Scribed by K. Rajewky; A. Cumano; R. Dildrop; C. Kocks; F. Sablitzky; M. Siekevitz


Book ID
112334732
Publisher
Springer
Year
1986
Tongue
English
Weight
122 KB
Volume
324
Category
Article
ISSN
1618-2650

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The affinity of hapten binding of monoclonal antibodies (MAbs) specific for 4-hydroxy-3-nitrophenylacetyl (NP) has been investigated at the molecular level by both site-specific mutagenesis and recombinant antibody construction, followed by expression in myeloma cells. We have shown that a single po