𝔖 Bobbio Scriptorium
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The Effect of Somatic Mutation on Antibody Affinitya

✍ Scribed by PATRICIA J. GEARHART


Book ID
118720379
Publisher
John Wiley and Sons
Year
1983
Tongue
English
Weight
324 KB
Volume
418
Category
Article
ISSN
0890-6564

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The affinity of hapten binding of monoclonal antibodies (MAbs) specific for 4-hydroxy-3-nitrophenylacetyl (NP) has been investigated at the molecular level by both site-specific mutagenesis and recombinant antibody construction, followed by expression in myeloma cells. We have shown that a single po