𝔖 Bobbio Scriptorium
✦   LIBER   ✦

The impact of cell adhesion changes on proliferation and survival during prostate cancer development and progression

✍ Scribed by Beatrice S. Knudsen; Cindy K. Miranti

Publisher
John Wiley and Sons
Year
2006
Tongue
English
Weight
269 KB
Volume
99
Category
Article
ISSN
0730-2312

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

In the normal prostate epithelium, androgen receptor (AR) negative basal epithelial cells adhere to the substratum, while AR expressing secretory cells lose substratum adhesion. In contrast, prostate cancer cells both express AR and adhere to a tumor basement membrane. In this review, we describe the differential expression of integrins, growth factor receptors (GFRs), and AR in normal and cancerous epithelium. In addition, we discuss how signals from integrins, GFRs, and AR are integrated to regulate the proliferation and survival of normal and malignant prostate epithelial cells. While cell adhesion is likely of great importance when considering therapeutic approaches for treatment of metastatic prostate cancer, no data on integrin expression are available from tissues of prostate cancer metastasis. However, several drug targets that are upregulated after androgen ablative therapy regulate cell adhesion and thus novel targeted therapies indirectly interfere with cell adhesion mechanisms in prostate cancer cells. J. Cell. Biochem. 99: 345–361, 2006. © 2006 Wiley‐Liss, Inc.

📜 SIMILAR VOLUMES

Role of the IGF-I receptor in the regula
Role of the IGF-I receptor in the regulation of cell–cell adhesion: Implications in cancer development and progression
✍ Loredana Mauro; Michele Salerno; Catia Morelli; Tom Boterberg; Marc E. Bracke; E 📂 Article 📅 2003 🏛 John Wiley and Sons 🌐 English ⚖ 287 KB

## Abstract The insulin‐like growth factor‐I receptor (IGF‐IR) is a ubiquitous multifunctional tyrosine kinase that has an important role in normal cell growth and development. However, abnormal stimulation of IGF‐IR signaling has been implicated in the development of different types of tumors. The

5α-androstane-3α,17β-diol supports human
5α-androstane-3α,17β-diol supports human prostate cancer cell survival and proliferation through androgen receptor-independent signaling pathways: Implication of androgen-independent prostate cancer progression
✍ Qing Yang; Mark A. Titus; Kar-Ming Fung; Hsueh-Kung Lin 📂 Article 📅 2008 🏛 John Wiley and Sons 🌐 English ⚖ 323 KB 👁 1 views

## Abstract Androgen and androgen receptor (AR) are involved in growth of normal prostate and development of prostatic diseases including prostate cancer. Androgen deprivation therapy is used for treating advanced prostate cancer. This therapeutic approach focuses on suppressing the accumulation of

The effect of receptor protein tyrosine
The effect of receptor protein tyrosine phosphatase kappa on the change of cell adhesion and proliferation induced by N-acetylglucosaminyltransferase V
✍ Can Wang; Zengxia Li; Zhaohua Yang; Hongbo Zhao; Yong Yang; Kangli Chen; Xiumei 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 English ⚖ 360 KB 👁 1 views

## Abstract __N__‐acetylglucosaminyltransferase V (GnT‐V) has been reported to be positively associated with tumor progression, but its mechanism still remains unknown. In the present study, we found that GnT‐V overexpression not only changed the glycosylation of receptor protein tyrosine phosphata

Chromosomal changes during progression o
Chromosomal changes during progression of transitional cell carcinoma of the bladder and delineation of the amplified interval on chromosome arm 8q
✍ Jochen Bruch; Gudrun Wöhr; Richard Hautmann; Torsten Mattfeldt; Silke Brüderlein 📂 Article 📅 1998 🏛 John Wiley and Sons 🌐 English ⚖ 123 KB

The cascade of genetic alterations leading to malignant transformation has been described for adenocarcinoma of the colon but is not established for other common tumor entities. In the present study, different stages of transitional cell carcinoma (TCC) of the bladder are analyzed by comparative gen