The androgen receptor gene and its influence on the development and progression of prostate cancer
โ Scribed by Jeffrey S. Montgomery; Douglas K. Price; William D. Figg
- Publisher
- John Wiley and Sons
- Year
- 2001
- Tongue
- English
- Weight
- 127 KB
- Volume
- 195
- Category
- Article
- ISSN
- 0022-3417
No coin nor oath required. For personal study only.
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## Background: Several recent studies have suggested an important role of the apoptosis suppressing bcl-2 gene product in prostate cancer progression to an androgen-insensitive disease. ## Methods: Using double-labeling techniques, we have investigated the nuclear androgen receptor (ar) status an
p53 protein expression of 30 hormone-refractory locally recurrent prostate cancers was compared with their matched untreated primary tumour specimens. In addition, androgen receptor (AR) gene amplification and p53 protein immunostaining were compared. p53 positivity increased during hormonal therapy