Ligand-independent activation of the androgen receptor in prostate cancer by growth factors and cytokines
β Scribed by Guido Jenster
- Publisher
- John Wiley and Sons
- Year
- 2000
- Tongue
- English
- Weight
- 55 KB
- Volume
- 191
- Category
- Article
- ISSN
- 0022-3417
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The effects of androgen manipulation on epidermal growth factor (EGF) receptor, p185 erbB-2 and transforming growth factor-β£ (TGF-β£) levels were examined in prostatic adenocarcinoma. Male nude mice were inoculated with the CWR22 androgen-dependent human prostatic tumor or an androgenindependent (CWR
Transforming growth factor-β£ (TGF-β£) and epidermal growth factor (EGF) are members of the EGF family of growth factors. They have a common receptor, the EGF receptor. This belongs to the tyrosine kinase group of receptors called the ErbB receptor family. Other members are ErbB-2, ErbB-3, and ErbB-4.
## Background: Hormones like bombesin (bn)/gastrin-releasing peptide (grp) and luteinizing hormone-releasing hormone (lh-rh) and growth factors such as epidermal growth factor (egf) might be involved in the relapse of prostate cancer under androgen ablation therapy. interference with receptors for