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The impact and role ofEGFRgene mutation on non-small cell lung cancer

✍ Scribed by Shinichi Toyooka; Junichi Soh; Hisayuki Shigematsu; Motoi Aoe; Hiroshi Date

Publisher: Springer
Year: 2006
Tongue: English
Weight: 367 KB
Volume: 58
Category: Article
ISSN: 0344-5704
DOI: 10.1007/s00280-006-0312-8

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## Abstract Mounting evidence has suggested somatic mutations in the __EGFR__ gene are associated with better responsiveness to __EGFR__ tyrosine kinase inhibitors (TKIs) in patients with non‐small‐cell lung cancer (NSCLC). Some, but not all, studies have reported that the mutations were more frequ