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The immunoglobulin kappa light chain repertoire expressed in the synovium of a patient with rheumatoid arthritis

✍ Scribed by Soo Kon Lee; S. Louis Bridges Jr.; William J. Koopman; Harry W. Schroeder Jr.

Publisher: John Wiley and Sons
Year: 1992
Tongue: English
Weight: 847 KB
Volume: 35
Category: Article
ISSN: 0004-3591
DOI: 10.1002/art.1780350809

No coin nor oath required. For personal study only.

✦ Synopsis

Objective.

To analyze the nature of the B cell response in the synovial tissue of a patient with rheumatoid arthritis (RA). Specifically, we sought to determine if the pattern of immunoglobulin expression was consistent with polyclonal stimulation of B cells or an antigen-driven response.

Methods. We generated an unrestricted complementary DNA (cDNA) library from the diseased synovium of a rheumatoid factor (RFkpositive patient with an 18-year history of RA. A random sample of K light chain recombinants was identified, and sequence analysis was performed. The variable domains were com-

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