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The IL-33/ST2 pathway: therapeutic target and novel biomarker

✍ Scribed by Kakkar, Rahul; Lee, Richard T.

Book ID
109950630
Publisher
Nature Publishing Group
Year
2008
Tongue
English
Weight
615 KB
Volume
7
Category
Article
ISSN
1474-1776

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## Background: St2 has been proposed to be a regulator of inflammation and th1/th2 balance. st2l is the il-33 membrane receptor and belongs to the il-1r family. the soluble variant, st2s, is identical to the extracellular region of st2l and competes for il-33 binding, inhibiting receptor signaling.